In all these cases, the cells die by apoptosis.Īpoptosis during the metamorphosis of a tadpole into a frog. In the developing nervous system, for example, cell death adjusts the number of nerve cells to match the number of target cells that require innervation. In many other cases, cell death helps regulate cell numbers. When a tadpole changes into a frog, the cells in the tail die, and the tail, which is not needed in the frog, disappears ( Figure 17-36). In other cases, cells die when the structure they form is no longer needed. Mouse paws, for example, are sculpted by cell death during embryonic development: they start out as spadelike structures, and the individual digits separate only as the cells between them die ( Figure 17-35). What purposes does this massive cell death serve? It seems remarkably wasteful for so many cells to die, especially as the vast majority are perfectly healthy at the time they kill themselves. In a healthy adult human, billions of cells die in the bone marrow and intestine every hour. ![]() In the developing vertebrate nervous system, for example, up to half or more of the nerve cells normally die soon after they are formed. The amount of apoptosis that occurs in developing and adult animal tissues can be astonishing. This process is therefore called programmed cell death, although it is more commonly called apoptosis (from a Greek word meaning “falling off,” as leaves from a tree). If cells are no longer needed, they commit suicide by activating an intracellular death program. ![]() The number of cells in this community is tightly regulated-not simply by controlling the rate of cell division, but also by controlling the rate of cell death. The cells of a multicellular organism are members of a highly organized community.
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